Open AccessSuccessful Bacterial Engraftment Identified by Next-Generation Sequencing Predicts Success of Fecal Microbiota Transplant for Clostridioides difficile
Author(s) -
Sabine Hazan,
Sonya Davé,
Andreas Papoutsis,
Brad Barrows,
Thomas J. Borody
Publication year - 2021
Publication title -
gastroenterology research
Language(s) - English
Resource type - Journals
eISSN - 1918-2813
pISSN - 1918-2805
DOI - 10.14740/gr1434
Subject(s) - clostridioides , fecal bacteriotherapy , medicine , feces , clostridium difficile , microbiology and biotechnology , biology , antibiotics
The effectiveness of fecal microbiota transplantation (FMT), a treatment for Clostridioides difficile infection (CDI), is dependent on successful engraftment (incorporation) of donor stool. We present a method for evaluating engraftment success based on next-generation sequencing (NGS)-based profiling of bacterial strains present in donor and recipient stool, and we suggest its potential to guide treatment decisions.