Open AccessEfficacy and Safety of Neostigmine and Decompressive Colonoscopy for Acute Colonic Pseudo-Obstruction: A Single-Center Analysis
Author(s) -
Joy Liu,
Vishnu Venkatesh,
Jing Gao,
Emerald P. Adler,
Darren M. Brenner
Publication year - 2021
Publication title -
gastroenterology research
Language(s) - English
Resource type - Journals
eISSN - 1918-2813
pISSN - 1918-2805
DOI - 10.14740/gr1394
Subject(s) - medicine , neostigmine , colonoscopy , adverse effect , surgery , prospective cohort study , anesthesia , colorectal cancer , cancer
Acute colonic pseudo-obstruction (ACPO) is characterized by acute colonic dilation in the absence of anatomical obstruction. Neostigmine is an acetylcholinesterase inhibitor recommended as first-line salvage therapy for uncomplicated ACPO. Decompressive colonoscopy is recommended if neostigmine is contraindicated or unsuccessful. There is a need to better characterize relative efficacy and factors impacting treatment choice. The aim of the study was to examine the use, efficacy, and safety of neostigmine and decompressive colonoscopy in the management of ACPO at a single academic center.