Open AccessPharmacological Alteration of Cellular Mechanical Properties in Pulmonary Arterial Smooth Muscle Cells of Idiopathic Pulmonary Arterial Hypertension
Author(s) -
Shinichi Katsuragi,
Nao Tatsumi,
Mizuki Matsumoto,
Jun Narita,
Ryo Ishii,
Hidehiro Suginobe,
Hirofumi Tsuru,
Renjie Wang,
Shigetoyo Kogaki,
Ryosuke Tanaka,
Keiichi Ozono,
Takeyoshi Okajima,
Hidekazu Ishida
Publication year - 2021
Publication title -
cardiology research
Language(s) - English
Resource type - Journals
eISSN - 1923-2837
pISSN - 1923-2829
DOI - 10.14740/cr1282
Subject(s) - medicine , cardiology , pulmonary hypertension
Idiopathic pulmonary arterial hypertension (IPAH) is a progressive disease caused by vascular remodeling of the pulmonary arteries with elevated pulmonary vascular resistance. Recently, various pulmonary vasodilator drugs have become available in the clinical field, and have dramatically ameliorated the prognosis of IPAH. However, little is known about how the mechanical properties of pulmonary arterial smooth muscle cells (PASMCs) are altered under drug supplementation.