Open AccessDiGeorge syndrome and immune thrombocytopenia purpura
Author(s) -
Amna Mohsin Mrcp,
Mahasin Shaheen Md Mrcp
Publication year - 2019
Publication title -
international journal of medicine
Language(s) - English
Resource type - Journals
ISSN - 2309-1622
DOI - 10.14419/ijm.v7i1.29732
Subject(s) - digeorge syndrome , thrombocytopenic purpura , medicine , immune system , pediatrics , immunology , purpura (gastropod) , biology , ecology , psychiatry
Digeorge Syndrome (22q11.2 deletion syndrome) comprises of various congenital anomalies such as cardiac defects, specific facial appearances, defective T cell production, hypocalcemia etc. This syndrome is also associated with various autoimmune diseases. Here we present a case report which shows association of Immune thrombocytopenia purpura with Digeorge Syndrome. A 15 years old boy born with congenital cardiac defects, diagnosed as 22q11.2 deletion syndrome, underwent corrective cardiac surgeries after birth. He developed thrombocytopenia at this age, requiring admission and platelet transfusions. His further work up confirmed Immune thrombocytopenic purpura and its presentation being related to the genetic disorder itself.