Open AccessEfficient Synthesis of Novel Thiazole Substituted Pyrrolidine Derivatives and their Antimicrobial Evaluation
Author(s) -
Mahendra B. Bodake,
Ghanshyam R. Jadhav,
Vijay Medhane,
Avinash D. Bholay
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22772
Subject(s) - thiazole , chemistry , pyrrolidine , moiety , antimicrobial , antifungal , stereochemistry , minimum inhibitory concentration , bacteria , combinatorial chemistry , molecule , proton nmr , organic chemistry , microbiology and biotechnology , genetics , biology
A series of new molecules containing pyrrolidine and thiazole moiety (4a-l) were designed andsynthesized. The structures of the synthesized compounds were characterized by IR, 1H NMR andmass spectral data. All the synthesized compounds were screened for their antibacterial activity againststrains of bacteria as well as antifungal activity against fungal strains. Minimum inhibitoryconcentrations (MICs) of all the synthesized compounds were determined. The screening of titlecompounds revealed that most of the tested compounds showed moderate to good microbial inhibitions