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High-performance computing (HPC) clusters are widely used in-house atscientific and academic research institutions. For some users, the transitionfrom running their analyses on a single workstation to running them on acomplex, multi-tenanted cluster, usually employing some degree of parallelism,can be challenging, if not bewildering, especially for users whose role is notpredominantly computational in nature. On the other hand, there are moreexperienced users, who can benefit from pointers on how to get the best fromtheir use of HPC.  This Ten Simple Rules guide is aimed at helping you identify ways to improveyour utilisation of HPC, avoiding common pitfalls that can negatively impactother users and will also help ease the load (pun intended) on your HPCsysadmin. It is intended to provide technical advice common to the use of HPCplatforms such as LSF, Slurm, PBS/Torque, SGE, LoadLeveler and YARN, thescheduler used with Hadoop/Spark platform.

Ten Simple Rules for Success with HPC, i.e. Responsibly BASHing that Linux Cluster