Open AccessMethod for the discrimination of superficial and deep absorption variations by time domain fNIRS
Author(s) -
Lucia Zucchelli,
Davide Contini,
Rebecca Re,
Alessandro Torricelli,
Lorenzo Spinelli
Publication year - 2013
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.4.002893
Subject(s) - optics , functional near infrared spectroscopy , time domain , gating , absorption (acoustics) , near infrared spectroscopy , focus (optics) , photon , spectroscopy , computer science , attenuation coefficient , materials science , physics , computer vision , biophysics , cognition , quantum mechanics , neuroscience , biology , prefrontal cortex
A method for the discrimination of superficial and deep absorption variations by time domain functional near infrared spectroscopy is presented. The method exploits the estimate of the photon time-dependent pathlength in different domains of the sampled medium and makes use of an approach based on time-gating of the photon distribution of time-of-flights. Validation of the method is performed in the two-layer geometry to focus on muscle and head applications. Numerical simulations varied the thickness of the upper layer, the interfiber distance, the shape of the instrument response function and the photon counts. Preliminary results from in vivo data are also shown.