Open AccessIn vivo feasibility of endovascular Doppler optical coherence tomography
Author(s) -
Cuiru Sun,
Felix Nolte,
Kyle H. Y. Cheng,
Barry Vuong,
Kenneth K. C. Lee,
Beau A. Standish,
Brian K. Courtney,
Thomas R. Marotta,
Adrian Mariampillai,
Victor X. D. Yang
Publication year - 2012
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.3.002600
Subject(s) - optical coherence tomography , doppler effect , biomedical engineering , optics , blood flow , preclinical imaging , materials science , tomography , flow velocity , radiology , medicine , physics , flow (mathematics) , in vivo , astronomy , biology , mechanics , microbiology and biotechnology
Feasibility of detecting intravascular flow using a catheter based endovascular optical coherence tomography (OCT) system is demonstrated in a porcine carotid model in vivo. The effects of A-line density, radial distance, signal-to-noise ratio, non-uniform rotational distortion (NURD), phase stability of the swept wavelength laser and interferometer system on Doppler shift detection limit were investigated in stationary and flow phantoms. Techniques for NURD induced phase shift artifact removal were developed by tracking the catheter sheath. Detection of high flow velocity (~51 cm/s) present in the porcine carotid artery was obtained by phase unwrapping techniques and compared to numerical simulation, taking into consideration flow profile distortion by the eccentrically positioned imaging catheter. Using diluted blood in saline mixture as clearing agent, simultaneous Doppler OCT imaging of intravascular flow and structural OCT imaging of the carotid artery wall was feasible. To our knowledge, this is the first in vivo demonstration of Doppler imaging and absolute measurement of intravascular flow using a rotating fiber catheter in carotid artery.