Open AccessFrontiers in non-union research
Author(s) -
Enrique GómezBarrena,
Norma G. Padilla-Eguiluz,
Philippe Rosset
Publication year - 2020
Publication title -
efort open reviews
Language(s) - English
Resource type - Journals
ISSN - 2396-7544
DOI - 10.1302/2058-5241.5.190062
Subject(s) - timeline , mesenchymal stem cell , medicine , non union , basic research , political science , computer science , surgery , pathology , library science , geography , archaeology
Multifactorial aetiology defines non-unions, with a biological and a mechanical distortion of the timeline of bone healing. Research on new advances to increase osteogenesis and promote non-union healing is strongly directed towards new forms of cell products. Basic science and research on non-union treatments is needed to compile preclinical data on new treatments. Bone marrow concentration and expanded mesenchymal stromal cells still require extensive clinical research to confirm efficacy in non-union treatment. Solid preclinical studies, precise cell product definition and preparation, and appropriate ethical and regulatory approvals are needed to assess new advanced therapy medicinal products. Cite this article: EFORT Open Rev 2020;5:574-583. DOI: 10.1302/2058-5241.5.190062