Open AccessTherapy-related acute promyelocytic leukemia with FMS-like tyrosine kinase 3-internal tandem duplication mutation in solitary bone plasmacytoma: A case report
Author(s) -
LiLi Hong,
Xianfu Sheng,
Haifeng Zhuang
Publication year - 2020
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v8.i19.4579
Subject(s) - medicine , acute promyelocytic leukemia , mutation , gene duplication , cancer research , tyrosine kinase , tyrosine kinase inhibitor , oncology , genetics , gene , receptor , cancer , retinoic acid , biology
Therapy-related acute promyelocytic leukemia (t-APL) is a rare complication observed in solitary bone plasmacytoma (SBP), and SBP after radiotherapy evolving to APL harboring the FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) mutation has never been reported. Here, we present the first case reported until now.