Open AccessHemophagocytic lymphohistiocytosis complicated by polyserositis: A case report
Author(s) -
Ping Zhu,
Qing Ye,
Tinghong Li,
Tao Han,
Fengmei Wang
Publication year - 2019
Publication title -
world journal of clinical cases
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v7.i19.3069
Subject(s) - medicine , hemophagocytosis , hepatosplenomegaly , hemophagocytic lymphohistiocytosis , cytopenia , pleural effusion , pericardial effusion , anasarca , leukopenia , serositis , rash , immunology , gastroenterology , bone marrow , arthritis , pancytopenia , chemotherapy , disease
Hemophagocytic lymphohistiocytosis (HLH) is a rare group of disorders of immune dysregulation characterized by clinical symptoms of severe inflammation. There are basically two types of clinical scenarios: Familial HLH and sporadic HLH. It is thought that the syndrome is implicated in the development of infections, malignancies, and autoimmune diseases. HLH, whether primary or secondary, is characterized by activated macrophages in hematopoietic organs, hepatosplenomegaly, cytopenia, and fever; however, HLH complicated with polyserositis (PS) has never been reported.