Open AccessNovel HNF1A gene mutation in maturity-onset diabetes of the young: A case report
Author(s) -
Qian Xu,
Chengxia Kan,
Ningning Hou,
Xiaodong Sun
Publication year - 2022
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v10.i6.1909
Subject(s) - medicine , hnf1a , sulfonylurea , maturity onset diabetes of the young , gliclazide , glucokinase , diabetes mellitus , glycemic , galactosemia , sanger sequencing , nonsense mutation , mutation , insulin , gene mutation , gene , endocrinology , type 2 diabetes , genetics , biology , missense mutation , galactose , biochemistry
Maturity-onset diabetes of the young 3 (MODY3), caused by mutations in the HNF1A gene, is the most common subtype of MODY. The diagnosis of MODY3 is critical because a low dose of sulfonylurea agents can achieve glucose control.