Open AccessThe Key Role of DNA Methylation and Histone Acetylation in Epigenetics of Atherosclerosis
Author(s) -
Han Teo Lee,
So-Yeon Oh,
Du Hyun Ro,
Hyerin Yoo,
Yoo-Wook Kwon
Publication year - 2020
Publication title -
journal of lipid and atherosclerosis
Language(s) - English
Resource type - Journals
eISSN - 2288-2561
pISSN - 2287-2892
DOI - 10.12997/jla.2020.9.3.419
Subject(s) - epigenetics , histone , dna methylation , epigenomics , histone methylation , cancer epigenetics , biology , acetylation , cancer research , genetics , microbiology and biotechnology , dna , histone methyltransferase , gene , gene expression
Atherosclerosis, which is the most common chronic disease of the coronary artery, constitutes a vascular pathology induced by inflammation and plaque accumulation within arterial vessel walls. Both DNA methylation and histone modifications are epigenetic changes relevant for atherosclerosis. Recent studies have shown that the DNA methylation and histone modification systems are closely interrelated and mechanically dependent on each other. Herein, we explore the functional linkage between these systems, with a particular emphasis on several recent findings suggesting that histone acetylation can help in targeting DNA methylation and that DNA methylation may control gene expression during atherosclerosis.