Open AccessExpression of P-glycoprotein and breast cancer resistance protein in three cases of canine lymphoma showing drug resistance
Author(s) -
Sachiko Hyokai,
Hiroyo Tanaka,
Noriyuki Aihara,
Junichi Kamiie
Publication year - 2021
Publication title -
journal of veterinary medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.51
H-Index - 60
eISSN - 1347-7439
pISSN - 0916-7250
DOI - 10.1292/jvms.20-0718
Subject(s) - abcg2 , lymphoma , p glycoprotein , canine lymphoma , drug resistance , multiple drug resistance , blood–brain barrier , medicine , breast cancer , immunohistochemistry , cancer , cancer research , pharmacology , atp binding cassette transporter , pathology , immunology , transporter , biology , gene , central nervous system , microbiology and biotechnology , biochemistry
In canine lymphoma, drug resistance is the major factor hindering treatment. In this study, we performed immunohistochemical examination of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), which are considered as transporters related to multidrug resistance in three recurrent canine lymphomas. All cases were negative for both transporters before anticancer drug administration, but became positive after this administration. The expression was confirmed in capillary endothelial cells, such as in brain capillaries acting as the blood-brain barrier (BBB). It is suggested that both transporters expressed on capillary endothelial cells in lymphoma tissue may inhibit the spread of anticancer drugs into tumor tissues from blood, the same as the BBB. Therefore, capillary endothelial cells could act as a blood-tumor barrier, which might be involved in drug resistance in canine lymphoma.