Open AccessHepatic neuroendocrine carcinoma with metastases to the lymph nodes in a sika deer (Cervus nippon yakushimae)
Author(s) -
Shibata Ritsu,
Yukino Machida,
Hitoshi Hatakeyama,
Hisashi Yoshimura,
Masami Yamamoto,
Kazuhiko Ochiai,
Kazuyoshi Uematsu,
Masaki Michishita
Publication year - 2020
Publication title -
journal of veterinary medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.51
H-Index - 60
eISSN - 1347-7439
pISSN - 0916-7250
DOI - 10.1292/jvms.19-0472
Subject(s) - cervus , lymph , carcinoma , medicine , oncology , neuroendocrine carcinoma , lymph node , biology , pathology , zoology
A 26-year and 6-month-old male sika deer that was kept at the Showa Park, Tokyo, Japan, collapsed and died of severe disease wasting and severe tabefaction. Grossly, numerous masses, 0.3-1.0 cm diameter, were dispersed throughout the liver. The multiple masses were composed of tumor cells, which had hypochromatic nuclei and abundant faintly eosinophilic cytoplasm, arranged in nests of various sizes. Immunohistochemically, tumor cells were positive for cytokeratin, chromogranin A, synaptophysin and gastrin. Ultrastructurally, the cytoplasm of the tumor cells contained abundant membrane-bound electron-dense granules. A metastatic lesion was observed in the renal, hepatic and pancreatic lymph nodes. On the basis of these findings, this tumor was diagnosed as a neuroendocrine carcinoma with metastases to the lymph nodes.