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Neural stem cells (NSCs) have the ability to regenerate, proliferate, and differentiate, enabling them to play important roles in the recovery of the damaged nervous system. However, in neurodegenerative diseases such as Alzheimer's disease (AD), the NSCs are damaged as well. Glia-like cells from human mesenchymal stem cells (ghMSCs) are functionally enhanced adult stem cells. In the present study, we investigated whether ghMSCs could protect NSCs from amyloid beta (Aβ)-mediated toxicity.

dementia and neurocognitive disorders/dementia and neurocognitive disorders

Glia-Like Cells from Human Mesenchymal Stem Cells Protect Neural Stem Cells in an<i>In Vitro</i>Model of Alzheimer's Disease by Reducing NLRP-3 Inflammasome

Glia-Like Cells from Human Mesenchymal Stem Cells Protect Neural Stem Cells in anIn VitroModel of Alzheimer's Disease by Reducing NLRP-3 Inflammasome