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The mitotic spindle is a very dynamic structure that is built de novo and destroyed at each round of cell division. In order to perform its fundamental function during chromosome segregation, mitotic spindle dynamics must be tightly coordinated with other cell cycle events. These changes are driven by several protein kinases, phosphatases and microtubule associated proteins. In budding yeast, the kinase Swe1 and the phosphatase Mih1 act in concert in controlling the phosphorylation state of Cdc28, the catalytic subunit of Cdk1, the major regulator of the cell cycle. In this study we show that Swe1 and Mih1 are also involved in the control of mitotic spindle dynamics. Our data indicate that Swe1 and the Polo-like kinase Cdc5 control the balance between phosphorylated and unphosphorylated forms of Mih1 that is in turn important for mitotic spindle elongation. Moreover we show that the microtubule associated protein Bik1 is a phosphoprotein and that Swe1 and Mih1 are both involved in controlling Bik1 phosphorylation state. These results uncover new players and provide insights into the complex regulation of mitotic spindle dynamics.

Novel insights into Swe1 and Mih1 role in the regulation of mitotic spindle dynamics