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GI stromal tumors (GISTs) are commonly associated with somatic mutations in KIT and PDGFRA . However, a subset arises from mutations in NF1 , most commonly associated with neurofibromatosis type 1. We define the anatomic distribution of NF1 alterations in GIST.

Duodenal-Jejunal Flexure GI Stromal Tumor Frequently Heralds Somatic NF1 and Notch Pathway Mutations