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:     The NF‐κB signaling network plays an important role in many different compartments of the immune system during immune activation. Using a computational model of the NF‐κB signaling network involving two negative regulators, IκBα and A20, we performed sensitivity analyses with three different sampling methods and present a ranking of the kinetic rate variables by the strength of their influence on the NF‐κB signaling response. We also present a classification of temporal‐response profiles of nuclear NF‐κB concentration into six clusters, which can be regrouped to three biologically relevant clusters. Last, we constructed a reduced network of the IKK–NF‐κB–IκBα–A20 signal transduction based on the ranking.

Sensitivity Analysis of a Computational Model of the IKK–NF‐κB–IκBα–A20 Signal Transduction Network