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Francisella novicida inhibits spontaneous apoptosis and extends human neutrophil lifespan
Author(s) -
Kinkead Lauren C.,
Fayram Drew C.,
Allen LeeAnn H.
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.4ma0117-014r
Subject(s) - francisella , biology , francisella tularensis , phagocytosis , neutrophil extracellular traps , microbiology and biotechnology , tularemia , opsonin , virulence , innate immune system , respiratory burst , immunology , inflammation , immune system , genetics , gene
F. novicida acts via the intrinsic and extrinsic pathways to prolong neutrophil viability by a mechanism independent of opsonins and phagocytosis.