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TLR9 is required for MAPK/NF‐κB activation but does not cooperate with TLR2 or TLR6 to induce host resistance to Brucella abortus
Author(s) -
Gomes Marco Túlio,
Campos Priscila Carneiro,
Pereira Guilherme de Sousa,
Bartholomeu Daniella Castanheira,
Splitter Gary,
Oliveira Sergio Costa
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.4a0815-346r
Subject(s) - tlr9 , biology , tlr2 , innate immune system , toll like receptor 9 , pattern recognition receptor , proinflammatory cytokine , immune system , brucella , microbiology and biotechnology , immunology , inflammation , brucellosis , gene expression , genetics , dna methylation , gene
TLR9 signaling through MAPK/NF‐κB pathways promotes proinflammatory responses, and helps control B. abortus infection in vivo independently of TLR2.