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ADAM17 controls IL‐6 signaling by cleavage of the murine IL‐6Rα from the cell surface of leukocytes during inflammatory responses
Author(s) -
Yan Isabell,
Schwarz Jeanette,
Lücke Karsten,
Schumacher Neele,
Schumacher Valéa,
Schmidt Stefanie,
Rabe Björn,
Saftig Paul,
Donners Marjo,
RoseJohn Stefan,
Mittrücker HansWilli,
Chalaris Athena
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a0515-207r
Subject(s) - biology , microbiology and biotechnology , immunology , cleavage (geology) , signal transduction , inflammation , cell , genetics , paleontology , fracture (geology)
ADAM17 balances IL‐6 signaling by shedding of the murine IL‐6Rα during infection and inflammation.