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CXCL1, but not IL‐6, significantly impacts intraocular inflammation during infection
Author(s) -
Parkunan Salai Madhumathi,
Randall C. Blake,
Astley Roger A.,
Furtado Glaucia C.,
Lira Sergio A.,
Callegan Michelle C.
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a0416-173r
Subject(s) - cxcl1 , inflammation , immunology , endophthalmitis , pathogenesis , cytokine , biology , chemokine , medicine , ophthalmology
Targeting CXCL1, but not IL6, reduced inflammation, protected retinal function, and minimized disease pathogenesis, resulting in an improved outcome for B. cereus intraocular infection.