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Serum amyloid A1α induces paracrine IL‐8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils
Author(s) -
De Buck Mieke,
Berghmans Nele,
Pörtner Noëmie,
Vanbrabant Lotte,
Cockx Maaike,
Struyf Sofie,
Opdenakker Ghislain,
Proost Paul,
Van Damme Jo,
Gouwy Mieke
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a0315-085r
Subject(s) - cxc chemokine receptors , serum amyloid a , chemokine , cxcl9 , chemokine receptor , cxcl2 , biology , ccr2 , chemotaxis , microbiology and biotechnology , receptor , chemistry , immunology , inflammation , biochemistry
SAA1α and paracrine‐induced IL‐8/CXCL8 synergize via direct binding to their corresponding GPCRs to provide enhanced neutrophil recruitment.