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Inhibition of pre‐B cell colony‐enhancing factor (PBEF/NAMPT/visfatin) decreases the ability of human neutrophils to generate reactive oxidants but does not impair bacterial killing
Author(s) -
Roberts Kate J.,
Cross Andrew,
Vasieva Olga,
Moots Robert J.,
Edwards Steven W.
Publication year - 2013
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.1012527
Subject(s) - nad+ kinase , nicotinamide phosphoribosyltransferase , respiratory burst , biology , phagocytosis , downregulation and upregulation , microbiology and biotechnology , pharmacology , immunology , cancer research , biochemistry , enzyme , gene
NAMPT inhibitors show potential as anti‐inflammatory or anti‐cancer agents by decreasing human neutrophilsˈ ability to generate a respiratory burst, with little impairment of bacterial killing.