Open AccessLipidomics unveils the complexity of the lipidome in metabolic diseases
Author(s) -
Lydic Todd A.,
Goo YoungHwa
Publication year - 2018
Publication title -
clinical and translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 1
ISSN - 2001-1326
DOI - 10.1186/s40169-018-0182-9
Subject(s) - lipidomics , lipidome , metabolomics , computational biology , lipid metabolism , bioinformatics , biology , biochemistry
Dysregulation of lipid metabolism is responsible for pathologies of human diseases including metabolic diseases. Recent advances in lipidomics analysis allow for the targeted and untargeted identification of lipid species and for their quantification in normal and diseased conditions. Herein, this review provides a brief introduction to lipidomics, highlights its application to characterize the lipidome at the cellular and physiological levels under different biological conditions, and discusses the potential for the use of lipidomics in the discovery of biomarkers.