English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Brain multimodal monitoring including intracranial pressure (ICP) and brain tissue oxygen pressure (PbtO 2 ) is more accurate than ICP alone in detecting cerebral hypoperfusion after traumatic brain injury (TBI). No data are available for the predictive role of a dynamic hyperoxia test in brain-injured patients from diverse etiology. Aim To examine the accuracy of ICP, PbtO 2  and the oxygen ratio (OxR) in detecting regional cerebral hypoperfusion, assessed using perfusion cerebral computed tomography (CTP) in patients with acute brain injury. Methods Single-center study including patients with TBI, subarachnoid hemorrhage (SAH) and intracranial hemorrhage (ICH) undergoing cerebral blood flow (CBF) measurements using CTP, concomitantly to ICP and PbtO 2  monitoring. Before CTP, FiO 2  was increased directly from baseline to 100% for a period of 20 min under stable conditions to test the PbtO 2  catheter, as a standard of care. Cerebral monitoring data were recorded and samples were taken, allowing the measurement of arterial oxygen pressure (PaO 2 ) and PbtO 2  at FiO 2  100% as well as calculation of OxR (= ΔPbtO 2 /ΔPaO 2 ). Regional CBF (rCBF) was measured using CTP in the tissue area around intracranial monitoring by an independent radiologist, who was blind to the PbtO 2  values. The accuracy of different monitoring tools to predict cerebral hypoperfusion (i.e., CBF &lt; 35 mL/100 g × min) was assessed using area under the receiver-operating characteristic curves (AUCs). Results Eighty-seven CTPs were performed in 53 patients (median age 52 [41–63] years—TBI,  n  = 17; SAH,  n  = 29; ICH,  n  = 7). Cerebral hypoperfusion was observed in 56 (64%) CTPs: ICP, PbtO 2  and OxR were significantly different between CTP with and without hypoperfusion. Also, rCBF was correlated with ICP ( r  = − 0.27;  p  = 0.01), PbtO 2  ( r  = 0.36;  p  &lt; 0.01) and OxR ( r  = 0.57;  p  &lt; 0.01). Compared with ICP alone (AUC = 0.65 [95% CI, 0.53–0.76]), monitoring ICP + PbO 2  (AUC = 0.78 [0.68–0.87]) or ICP + PbtO 2  + OxR (AUC = 0.80 (0.70–0.91) was significantly more accurate in predicting cerebral hypoperfusion. The accuracy was not significantly different among different etiologies of brain injury. Conclusions The combination of ICP and PbtO 2  monitoring provides a better detection of cerebral hypoperfusion than ICP alone in patients with acute brain injury. The use of dynamic hyperoxia test could not significantly increase the diagnostic accuracy.

Detection of cerebral hypoperfusion with a dynamic hyperoxia test using brain oxygenation pressure monitoring