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Steroid-induced osteonecrosis of the femoral head (ONFH) is a disease of the bone. Metabolism and genetic factors are generally considered to play an important role. The purpose of this study was to investigate the relationship between single-nucleotide polymorphisms (SNPs) in  MIR17HG  and  MIR155HG  and the risk of steroid-induced ONFH in the population of northern China.    Methods  A total of 199 steroid-induced ONFH patients and 506 healthy controls were recruited for the study. Four SNPs of  MIR17HG  and seven SNPs of  MIR155HG  were genotyped by Sequenom MassARRAY. ORs and 95% CIs were used to evaluate the relationship between these SNPs and steroid-induced ONFH.    Results  In the codominant model, patients with the  MIR17HG  SNPs (rs7318578) AA genotype had an increased risk of steroid-induced ONFH (OR = 1.79,  p  = 0.039); in the recessive model, patients with the  MIR17HG  SNP (rs7318578) AA genotype had an increased risk of steroid-induced ONFH (OR = 1.78,  p  = 0.032). Stratified analysis showed that a  MIR17HG  SNP (rs7318578) and the  MIR155HG  SNPs (rs77218221, rs11911469, rs34904192 and rs4143370) were closely related to different unornamented phenotypes of steroid-induced ONFH. Analysis of the clinical indicators revealed significant differences in high-density lipoprotein ( HDL-C ) levels between the ONFH group and the control group ( p  = 0.005). In the MIR17HG SNP (rs75267932), patients with different genotypes had different levels of triglyceride ( TG ). The MIR155HG SNPs (rs77699734, rs1893650, and rs34904192) showed differences in triglyceride ( TG ), high-density lipoprotein ( HDL-C ) and low-density lipoprotein ( LDL-C ) levels in patients with different genotypes.    Conclusion  Our results confirm that  MIR17HG  and  MIR155HG  gene mutations are associated with steroid-induced ONFH susceptibility in the population of northern China, providing new evidence for the early detection and prevention of ONFH.

Association of MIR17HG and MIR155HG gene variants with steroid-induced osteonecrosis of the femoral head in the population of northern China