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HighlightsCD40  expression correlates with the type I anti-tumor response and better survival.    Pan-cancer bioinformatics characterization reveals reduced  CD40  expression in 11 cancer types, including  RAS   mut   melanoma compared to nevi.RAS  mutation correlates with reduced  CD40  expression in malignant melanoma.CD40  expression is associated with better response to immune checkpoint blockade therapy in melanoma.Supplementary Information  The online version contains supplementary material available at 10.1186/s12943-021-01442-3.

Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy