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Background Recurrent aphthous stomatitis (RAS) is multifactorial disease with unclear etiopathogenesis. The aim of this study was to determine distribution of the angiotensin I converting enzyme ( ACE)  gene polymorphisms and their influence on RAS susceptibility in Czech population. Methods The study included 230 subjects (143 healthy controls and 87 patients with RAS) with anamnestic, clinical and laboratory data. Five  ACE  gene polymorphisms (rs4291/rs4305/rs4311/rs4331/rs1799752 =  ACE  I/D) were determined by TaqMan technique. Results The allele and genotype distributions of the studied  ACE  I/D polymorphisms were not significantly different between subjects with/without RAS ( P  corr  &gt; 0.05). However, carriers of II genotype were less frequent in the RAS group (OR = 0.48, 95% CI = 0.21–1.12,  P  = 0.059). Stratified analysis by sex demonstrated lower frequency of II genotype in women (OR = 0.33, 95% CI = 0.09–1.17,  P    0.05, respectively) than in men with RAS ( P  &gt; 0.05). Moreover, the frequency of AGTGD haplotype was significantly increased in RAS patients (OR = 13.74, 95% CI = 1.70–110.79,  P  = 0.0012,  P  corr    0.05). Conclusions Our study indicates that while the AGTGD and TGD haplotypes are associated with increased risk of RAS development, CGI haplotype might be one of protective factors against RAS susceptibility in Czech population.

bmc oral health

Association of the angiotensin I converting enzyme (ACE) gene polymorphisms with recurrent aphthous stomatitis in the Czech population: case–control study