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Background In recent years, total hip arthroplasty via the direct anterior approach (DAA) has become more common. Little is known on the influence of the surgical approach on the microbiological spectrum and resistance pattern in periprosthetic hip joint infections. The aim of the present study was to evaluate the microbiological spectrum and resistance pattern in periprosthetic hip joint infections comparing the direct anterior versus lateral approach in a matched-cohort analysis at a single institution. Methods Patients who underwent revision hip arthroplasty due to PJI following primary total hip arthroplasty with culture positive microbiology were analyzed. In all study patients, both the primary surgery and the revisions surgery were performed at the same institution. Only patients in whom primary surgery was performed via a direct anterior or lateral approach were included ( n  = 87). A matched cohort analysis was performed to compare the microbiological spectrum and resistance pattern in PJI following direct anterior ( n  = 36) versus lateral ( n  = 36) primary THA. Results We identified both a significantly different microbiological spectrum and resistance pattern in PJI comparing direct anterior versus lateral approach THA.  Cutibacterium avidum  was obtained more frequently in the anterior subgroup (22.2% vs. 2.8%,  p  = 0.028). In the subgroup of infections with  Staphylococcus aureus  ( n  = 12), methicillin resistance was detected in 3/5 cases in the direct anterior group versus 0/7 cases in the lateral group ( p  = 0.045). Overall,  Staphylococcus epidermidis  was the most common causative microorganism in both groups (direct anterior: 36.1%; lateral: 27.8%,  p  = 0.448). Conclusion The present study indicates a potential influence of the localization of the skin incision in THA on the microbiological spectrum and resistance pattern in PJI.  Cutibacterium avidum  seemed to be a more common causative microorganism in PJI in patients who underwent direct anterior compared to lateral approach THA.

bmc musculoskeletal disorders

Differential microbiological spectrum and resistance pattern in periprosthetic hip joint infections: a matched-cohort analysis comparing direct anterior versus lateral approach