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Background  Identifying the biological subclasses of septic shock might provide specific targeted therapies for the treatment and prognosis of septic shock. It might be possible to find biological markers for the early prediction of septic shock prognosis.    Methods  The data were obtained from the Gene Expression Omnibus databases (GEO) in NCBI. GO enrichment and KEGG pathway analyses were performed to investigate the functional annotation of up- and downregulated DEGs. ROC curves were drawn, and their areas under the curves (AUCs) were determined to evaluate the predictive value of the key genes.    Results  117 DEGs were obtained, including 36 up- and 81 downregulated DEGs. The AUC for the  MME  gene was 0.879, as a key gene with the most obvious upregulation in septic shock. The AUC for the  THBS1  gene was 0.889, as a key downregulated gene with the most obvious downregulation in septic shock.    Conclusions  The upregulation of  MME  via the renin-angiotensin system pathway and the downregulation of  THBS1  through the PI3K–Akt signaling pathway might have implications for the early prediction of prognosis of septic shock in patients with pneumopathies.

Identification of transcriptomics biomarkers for the early prediction of the prognosis of septic shock from pneumopathies