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Background   Helicobacter pylori  ( H. pylori ) is the causative agent of stomach diseases such as duodenal ulcer and gastric cancer, in this regard incomplete eradication of this bacterium has become to a serious concern. Probiotics are a group of the beneficial bacteria which increase the cure rate of  H. pylori  infections through various mechanisms such as competitive inhibition, co-aggregation ability, enhancing mucus production, production of bacteriocins, and modulating immune response.    Result  In this study, according to the received articles, the anti- H. pylori  activities of probiotics were reviewed. Based on studies, administration of standard antibiotic therapy combined with probiotics plays an important role in the effective treatment of  H. pylori  infection. According to the literature,  Lactobacillus casei ,  Lactobacillus reuteri ,  Lactobacillus rhamnosus  GG, and  Saccharomyces boulardii  can effectively eradicate  H. pylori  infection. Our results showed that in addition to decrease gastrointestinal symptoms, probiotics can reduce the side effects of antibiotics (especially diarrhea) by altering the intestinal microbiome.    Conclusion  Nevertheless, antagonist activities of probiotics are  H. pylori  strain-specific. In general, these bacteria can be used for therapeutic purposes such as adjuvant therapy, drug-delivery system, as well as enhancing immune system against  H. pylori  infection.

Probiotics as the live microscopic fighters against Helicobacter pylori gastric infections