Open AccessDysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies
Author(s) -
ChanWang Jerry Lio,
Hiroshi Yuita,
Anjana Rao
Publication year - 2019
Publication title -
blood
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.515
H-Index - 465
eISSN - 1528-0020
pISSN - 0006-4971
DOI - 10.1182/blood.2019791475
Subject(s) - biology , epigenetics , dna methylation , genome instability , cancer research , gene silencing , cpg site , carcinogenesis , dna demethylation , genetics , gene , dna , gene expression , dna damage
TET2 is frequently mutated in lymphoid and myeloid malignancy. Lio et al review the current understanding of the role of TET enzymes in lymphoid and myeloid malignancy, highlighting that loss of TET protein function can occur either by mutation or as a result of metabolic alteration.
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