Open AccessGene alterations in epigenetic modifiers and JAK-STAT signaling are frequent in breast implant-associated ALCL.
Author(s) -
Camille Laurent,
Aliicolae,
Cécile Laurent,
Fabien Le Bras,
Corinne Haïoun,
Virginie Fataccioli,
Nadia Amara,
José Adélaı̈de,
Arnaud Guillé,
JeanMarc Schiano de Colella,
Bruno Tesson,
Alexandra TraverseGlehen,
MariePierre Chenard,
Lénaïg Mescam,
Philippe Moreau,
Catherine ChassagneClément,
Joan Somja,
Fréderic Escudié,
Marc André,
Nadine Martin,
Laetitia Lacroix,
François Lemonnier,
AnneSophie Hamy,
Fabien Reyal,
Marie Bannier,
Lucie Oberic,
Naïs Prade,
François-Xavier Frénois,
Asma BeldiFerchiou,
MarieHélène DelfauLarue,
Réda Bouabdallah,
Daniel Birnbaum,
Pierre Brousset,
Luc Xerri,
Philippe Gaulard
Publication year - 2019
Publication title -
blood
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.515
H-Index - 465
eISSN - 1528-0020
pISSN - 0006-4971
DOI - 10.1182/blood.2019001904
Subject(s) - epigenetics , exome sequencing , stat , carcinogenesis , cancer research , biology , jak stat signaling pathway , gene , genetics , dna methylation , medicine , signal transduction , bioinformatics , mutation , gene expression , stat3 , receptor tyrosine kinase
Key Points An accumulation of alterations in epigenetic modifiers and genes in the JAK/STAT pathway likely drives BI-ALCL oncogenesis. Whole exome sequencing of a large series of BI-ALCL demonstrates recurrent mutations in epigenetic regulators.
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