Open AccessMolecular roulette: nucleophosmin mutations in AML are orchestrated through N-nucleotide addition by TdT
Author(s) -
Julian Borrow,
Sara A. Dyer,
Susanna Akiki,
Mike Griffiths
Publication year - 2019
Publication title -
blood
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.515
H-Index - 465
eISSN - 1528-0020
pISSN - 0006-4971
DOI - 10.1182/blood.2019001240
Subject(s) - nucleophosmin , npm1 , terminal deoxynucleotidyl transferase , biology , genetics , cancer research , microbiology and biotechnology , myeloid leukemia , gene , apoptosis , karyotype , tunel assay , chromosome
These complementary papers by Borrow et al report persuasive but indirect evidence that the lymphoid enzyme terminal deoxynucleotidyl transferase (TdT) is the mutagen responsible for 2 common pathogenic genetic changes in acute myeloid leukemia (AML): FLT3-ITD and NPM1.
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