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Clinical Research Tyrosine Turnover and Protein Synthesis During Parenteral Nutrition
Author(s) -
Wells Frank E.,
Smits Bernard J.
Publication year - 1980
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860718000400303
Subject(s) - tyrosine , parenteral nutrition , phenylalanine , protein turnover , oxidative phosphorylation , medicine , protein biosynthesis , chemistry , endocrinology , biochemistry , amino acid
Three patients receiving total parenteral nutrition and one healthy subject receiving 5% glucose were infused for 10 hours with L‐(U 14 C)tyrosine (1.5μCi/hr). Two alternative assumptions were made regarding the fate of labeled carbon. Total and oxidative fluxes of tyrosine were calculated and these were used to determine rates of protein synthesis arid breakdown. Patients showed positive net protein synthesis and oxidation of infused phenylalanine via tyrosine was shown not to be excessive.