Open AccessThe Ciliary Muscle and Zonules of Zinn Modulate Lens Intracellular Hydrostatic Pressure Through Transient Receptor Potential Vanilloid Channels
Author(s) -
Yadi Chen,
Junyuan Gao,
Leping Li,
Caterina Sellitto,
Richard T. Mathias,
Paul J. Donaldson,
Thomas W. White
Publication year - 2019
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.19-27794
Subject(s) - hydrostatic pressure , transient receptor potential channel , intracellular , ciliary body , chemistry , ciliary muscle , trpv1 , biophysics , microbiology and biotechnology , biology , receptor , biochemistry , neuroscience , physics , accommodation , thermodynamics
Lenses have an intracellular hydrostatic pressure gradient to drive fluid from central fiber cells to surface epithelial cells. Pressure is regulated by a feedback control system that relies on transient receptor potential vanilloid (TRPV)1 and TRPV4 channels. The ciliary muscle transmits tension to the lens through the zonules of Zinn. Here, we have examined if ciliary muscle tension influenced the lens intracellular hydrostatic pressure gradient.