Open AccessCharacterization of LSD1 Expression Within the Murine Eye
Author(s) -
Salma Ferdous,
Hans E. Grossniklaus,
Jeffrey H Boatright,
John M. Nickerson
Publication year - 2019
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.19-26728
Subject(s) - retina , retinal , microbiology and biotechnology , biology , outer nuclear layer , inner nuclear layer , biophysics , cornea , chemistry , anatomy , neuroscience , biochemistry
The purpose of this study was to extend the current understanding of endogenous lysine-specific demethylase 1 (LSD1) expression spatially and temporally in the retina. Toward that end, we determined the localization and levels of LSD1 and its substrates H3K4me1 and H3K4me2 (H3K4me1/2) within the murine eye.