Open AccessSpecific Pharmacological Profile of A 2A Adenosine Receptor Predicts Reduced Fractional Flow Reserve in Patients With Suspected Coronary Artery Disease
Author(s) -
Paganelli Franck,
Resseguier Noémie,
Marlinge Marion,
Laine Marc,
Malergue Fabrice,
Kipson Nathalie,
Armangau Pauline,
Pezzoli Nicolas,
Kerbaul Francois,
Bonello Laurent,
Mottola Giovanna,
Fenouillet Emmanuel,
Guieu Régis,
Ruf Jean
Publication year - 2018
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.117.008290
Subject(s) - medicine , fractional flow reserve , coronary artery disease , cardiology , interquartile range , electrocardiography , chest pain , myocardial infarction , coronary angiography
The rapid and reliable exclusion of myocardial revascularization is a major unmet clinical need in patients with suspected coronary artery disease (CAD) and non-contributive electrocardiography and troponin. Non-invasive tests have high rates of false positives and negatives, and there is no biomarker to assess myocardial ischemia. The presence of spare adenosine A 2A receptors (A 2 A R)-characterized by a high dissociation constant/half maximal effective concentration (K D /EC 50 ) ratio-expressed on peripheral blood mononuclear cells (PBMC) has been associated with ischemia during exercise stress testing in patients with CAD. In this work, we investigated the diagnostic accuracy of spare A 2 A R versus fractional flow reserve (FFR) in patients with suspected CAD.