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The rapid and reliable exclusion of myocardial revascularization is a major unmet clinical need in patients with suspected coronary artery disease (CAD) and non-contributive electrocardiography and troponin. Non-invasive tests have high rates of false positives and negatives, and there is no biomarker to assess myocardial ischemia. The presence of spare adenosine A 2A receptors (A 2  A R)-characterized by a high dissociation constant/half maximal effective concentration (K D /EC 50 ) ratio-expressed on peripheral blood mononuclear cells (PBMC) has been associated with ischemia during exercise stress testing in patients with CAD. In this work, we investigated the diagnostic accuracy of spare A 2  A R versus fractional flow reserve (FFR) in patients with suspected CAD.

journal of the american heart association

Specific Pharmacological Profile of A 2A  Adenosine Receptor Predicts Reduced Fractional Flow Reserve in Patients With Suspected Coronary Artery Disease