Open AccessDipeptidyl Peptidase‐4 Inhibition Potentiates Stimulated Growth Hormone Secretion and Vasodilation in Women
Author(s) -
Wilson Jessica R.,
Brown Nancy J.,
Nian Hui,
Yu Chang,
Bidlingmaier Martin,
Devin Jessica K.
Publication year - 2018
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.117.008000
Subject(s) - sitagliptin , medicine , endocrinology , dipeptidyl peptidase 4 inhibitor , vasodilation , dipeptidyl peptidase 4 , plasminogen activator , placebo , insulin , diabetes mellitus , type 2 diabetes , metformin , alternative medicine , pathology
Diminished growth hormone (GH) is associated with impaired endothelial function and fibrinolysis. GH-releasing hormone is the primary stimulus for GH secretion and a substrate of dipeptidyl peptidase-4. We tested the hypothesis that dipeptidyl peptidase-4 inhibition with sitagliptin increases stimulated GH secretion, vasodilation, and tissue plasminogen activator (tPA) activity.