English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Background  No prospective study of the relationship between intima–media thickness ( IMT ) progression and incident cardiovascular disease ( CVD ) has been performed.    Methods and Results  We studied 4724 participants (mean age: 59.7±11.9 years; without  CVD  at the baseline) who had carotid ultrasonographic measurement of  IMT  on both sides of the entire carotid artery area (ie, the entire scanned common carotid artery [CCA], carotid artery bulb, internal carotid artery, and external carotid artery areas for both sides) between April 1994 and August 2001. Carotid ultrasonographic follow‐up was performed every 2 years between April 1994 and March 2005 in 2722 of these participants, newly revealing 193  CCA  plaques (maximum  IMT  in the CCA >1.1 mm). We followed up for incident  CVD  until December 2013. Statistical analyses were performed using a Cox proportional hazards regression model, evaluated using C statistics, and net reclassification improvement. During the 59 909 person‐years of follow‐up, we observed 221 strokes and 154 coronary heart disease events.  CCA  plaque and maximum  IMT  in the whole carotid artery area >1.7 mm were risk factors for  CVD .  CCA  plaque presented an increased risk of  CVD  based on C statistics and the reclassification improvement of the current risk prediction model. After adding the new incident  CCA  plaques, during the 23 702 person‐years of follow‐up, 69 strokes and 43 coronary heart disease events occurred. The adjusted hazard ratios for incident  CCA  plaque were 1.95 (95% confidence interval, 1.14–3.30) in  CVD  and 2.01 (95% confidence interval, 1.01–3.99) in stroke.    Conclusions  Maximum  IMT  in the CCA contributed significantly but modestly to the predictive power of incident  CVD  used in calculating traditional risk factors. This study provides the first demonstration that new progression of incident  CCA  plaque is a  CVD  risk.

Impact of Intima–Media Thickness Progression in the Common Carotid Arteries on the Risk of Incident Cardiovascular Disease in the Suita Study