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Background  The 2008 Physical Activity Guidelines for Americans recommends that adults accumulate moderate‐to‐vigorous physical activity ( MVPA ) in bouts of ≥10 minutes for substantial health benefits. To what extent the same amount of  MVPA  accumulated in bouts versus sporadically reduces mortality risk remains unclear.    Methods and Results  We analyzed data from the National Health and Nutrition Examination Survey 2003–2006 and death records available through 2011 (follow‐up period of ≈6.6 years; 700 deaths) to examine the associations between objectively measured physical activity accumulated with and without a bout criteria and all‐cause mortality in a representative sample of  US  adults 40 years and older (n=4840). Physical activity data were processed to generate minutes per day of total and bouted  MVPA . Bouted  MVPA  was defined as  MVPA  accumulated in bouts of a minimum duration of either 5 or 10 minutes allowing for 1‐ to 2‐minute interruptions. Hazard ratios for all‐cause mortality associated with total and bouted  MVPA  were similar and ranged from 0.24 for the third quartile of total to 0.44 for the second quartile of 10‐minute bouts. The examination of jointly classified quartiles of total  MVPA  and tertiles of proportion of bouted activity revealed that greater amounts of bouted  MVPA  did not result in additional risk reductions for mortality.    Conclusions  These results provide evidence that mortality risk reductions associated with  MVPA  are independent of how activity is accumulated and can impact the development of physical activity guidelines and inform clinical practice.

Moderate‐to‐Vigorous Physical Activity and All‐Cause Mortality: Do Bouts Matter?