Open AccessGenome Wide Association Study Identifies the HMGCS2 Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients
Author(s) -
Singh Sonal,
McDonough Caitrin W.,
Gong Yan,
Alghamdi Wael A.,
Arwood Meghan J.,
Bargal Salma A.,
Dumeny Leanne,
Li WenYi,
Mehanna Mai,
Stockard Bradley,
Yang Guang,
Oliveira Felipe A.,
Fredette Natalie C.,
Shahin Mohamed H.,
Bailey Kent R.,
Beitelshees Amber L.,
Boerwinkle Eric,
Chapman Arlene B.,
Gums John G.,
Turner Stephen T.,
CooperDeHoff Rhonda M.,
Johnson Julie A.
Publication year - 2018
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.117.007339
Subject(s) - medicine , chlorthalidone , genome wide association study , locus (genetics) , genetic association , cardiology , genome , genetics , gene , genotype , single nucleotide polymorphism , biology , blood pressure
Thiazide and thiazide-like diuretics are first-line medications for treating uncomplicated hypertension. However, their use has been associated with adverse metabolic events, including hyperglycemia and incident diabetes mellitus, with incompletely understood mechanisms. Our goal was to identify genomic variants associated with thiazide-like diuretic/chlorthalidone-induced glucose change.