Open AccessRandomized Trial of the Effects of Insulin and Metformin on Myocardial Injury and Stress in Diabetes Mellitus: A Post Hoc Exploratory Analysis
Author(s) -
Srivastava Pratyaksh K.,
Pradhan Aruna D.,
Cook Nancy R.,
Ridker Paul M,
Everett Brendan M.
Publication year - 2017
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.117.007268
Subject(s) - medicine , metformin , insulin glargine , type 2 diabetes mellitus , diabetes mellitus , type 2 diabetes , endocrinology , glycated hemoglobin , insulin , cardiology , glycemic
Subclinical myocardial injury, as measured by high-sensitivity cardiac troponin T (hsTnT), and myocardial stress, as measured by N-terminal pro-B-type natriuretic peptide (NT-proBNP), are related to glycemic control in patients with type 2 diabetes mellitus, and are strong predictors of adverse cardiovascular outcomes. We sought to determine whether antihyperglycemic therapy improves measures of myocardial injury and myocardial stress in patients with type 2 diabetes mellitus.