English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the zaia usage as premium feature

ZAIA

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the access of premium content as premium feature

Premium Content

Zendy Tools

Zendy Open

Background  In cardiac resynchronization therapy ( CRT ), quadripolar ( QUAD ) left ventricular ( LV ) leads are less prone to postoperative complications than non‐ QUAD  leads. Some studies have suggested better clinical outcomes.    Methods and Results  Clinical events were assessed in 847 patients after  CRT ‐pacing or CRT‐defibrillation using either  QUAD  (n=287) or non‐ QUAD  (n=560), programmed to single‐site site  LV  pacing. Over a follow‐up period of 3.2 years (median [interquartile range, 1.90–5.0]),  QUAD  was associated with a lower total mortality (adjusted hazard ratio [ aHR ]: 0.32, 95% confidence interval [ CI ], 0.20–0.52), cardiac mortality ( aHR : 0.36, 95%  CI , 0.20–0.65), and heart failure ( HF ) hospitalization ( aHR : 0.62, 95%  CI , 0.39–0.99), after adjustment for age, sex, New York Heart Association class,  HF  etiology, device type ( CRT ‐pacing or  CRT ‐defibrillation), comorbidities, atrial rhythm, medication, left ventricular ejection fraction, and creatinine. Death from pump failure was lower with  QUAD  ( aHR : 0.33; 95%  CI , 0.18–0.62), but no group differences emerged with respect to sudden cardiac death. There were no differences in implant‐related complications. Re‐interventions for  LV  displacement or phrenic nerve stimulation, which were lower with  QUAD , predicted total mortality ( aHR : 1.68, 95%  CI , 1.11–2.54), cardiac mortality ( aHR : 2.61, 95%  CI , 1.66–4.11) and  HF  hospitalization ( aHR : 2.09, 95% CI, 1.22–3.58).    Conclusions   CRT  using  QUAD , programmed to biventricular pacing with single‐site  LV  pacing, is associated with a lower total mortality, cardiac mortality, and  HF  hospitalization. These trends were observed for both  CRT ‐defibrillation and  CRT ‐pacing, after adjustment for  HF  cause and other confounders. Re‐intervention for  LV  lead displacement or phrenic nerve stimulation was associated with worse outcomes.

journal of the american heart association

Cardiac Resynchronization Therapy Using Quadripolar Versus Non‐Quadripolar Left Ventricular Leads Programmed to Biventricular Pacing With Single‐Site Left Ventricular Pacing: Impact on Survival and Heart Failure Hospitalization