Open AccessGenetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β‐Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil‐SR Trandolapril Study) Trials
Author(s) -
Magvanjav Oyunbileg,
Gong Yan,
McDonough Caitrin W.,
Chapman Arlene B.,
Turner Stephen T.,
Gums John G.,
Bailey Kent R.,
Boerwinkle Eric,
Beitelshees Amber L.,
Tanaka Toshihiro,
Kubo Michiaki,
Pepine Carl J.,
CooperDeHoff Rhonda M.,
Johnson Julie A.
Publication year - 2017
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.117.006522
Subject(s) - medicine , trandolapril , odds ratio , thiazide , combination therapy , confidence interval , blood pressure , diuretic , single nucleotide polymorphism , hydrochlorothiazide , pharmacology , bioinformatics , genetics , ace inhibitor , angiotensin converting enzyme , biology , gene , genotype
The majority of hypertensive individuals require combination antihypertensive therapy to achieve adequate blood pressure (BP) control. This study aimed to identify genetic variants associated with uncontrolled BP on combination therapy with a thiazide diuretic and a β-blocker.