English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Background  Left ventricular ( LV ) hypertrophy and subclinical cerebrovascular disease are early manifestations of cardiac and brain target organ damage caused by hypertension. This study aimed to investigate whether intensive office systolic blood pressure ( SBP ) control has beneficial effects on  LV  morphology and function and subclinical cerebrovascular disease in elderly patients with hypertension.    Methods and Results  We examined 420 patients treated for hypertension without history of heart failure and stroke from the  CABL  (Cardiovascular Abnormalities and Brain Lesions) study. All patients underwent 2‐dimensional echocardiographic examination and brain magnetic resonance imaging. Subclinical cerebrovascular disease was defined as silent brain infarcts and white matter hyperintensity volume. Patients were divided into 3 groups: SBP <120 mm Hg (intensive control);  SBP  120 to 139 mm Hg (less intensive control); and  SBP  ≥140 mm Hg (uncontrolled). Prevalence of  LV  hypertrophy and diastolic dysfunction were lowest in the intensive control, intermediate in the less intensive control, and highest in the uncontrolled groups (12.8%, 31.8%, and 44.7%, respectively [ P <0.001], for  LV  hypertrophy; 46.8%, 61.7%, and 72.6%, respectively [ P =0.003], for diastolic dysfunction). Patients with less intensive  SBP  control had greater risk of  LV  hypertrophy than those with intensive control (adjusted odds ratio, 3.26;  P =0.013). A similar trend was observed for  LV  diastolic dysfunction but did not reach statistical significance (adjusted odds ratio, 1.65;  P =0.144). Conversely, intensive  SBP  control was not significantly associated with reduced risk of silent brain infarcts and white matter hyperintensity volume compared with less intensive control.    Conclusions  Compared with less intensive control, intensive  SBP  control may have a stronger beneficial effect on cardiac than cerebral subclinical disease.

Association of Blood Pressure Control Level With Left Ventricular Morphology and Function and With Subclinical Cerebrovascular Disease