Open AccessBlood–Brain Barrier Disruption, Vascular Impairment, and Ischemia/Reperfusion Damage in Diabetic Stroke
Author(s) -
Venkat Poornima,
Chopp Michael,
Chen Jieli
Publication year - 2017
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.117.005819
Subject(s) - medicine , stroke (engine) , ischemia , cardiology , diabetes mellitus , blood–brain barrier , vascular disease , brain ischemia , central nervous system , endocrinology , engineering , mechanical engineering
Stroke is a major cause of death and long‐term disability accompanied by steep social and medical costs. Diabetes mellitus (DM) is a chronic, lifelong, severe metabolic health problem characterized by hyperglycemia, attributable to insulin deficiency, insulin resistance, or a combination of both.