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Background  Proprotein convertase subtilisin/kexin type 9 (PCSK9) circulating levels are significantly associated with an increased risk of cardiovascular events. This study aimed to evaluate the relationship between circulating levels of  PCSK 9 and arterial stiffness, an early instrumental biomarker of cardiovascular disease risk, in a large sample of overall healthy participants.    Methods and Results  From the historical cohort of the Brisighella Heart Study, after exclusion of active smokers, participants in secondary prevention for cardiovascular disease, and patients in treatment with statins or vasodilating agents, we selected 227 premenopausal women and 193 age‐matched men and 460 postmenopausal women and 416 age‐matched men. In these participants, we evaluated the correlation between  PCSK 9 plasma circulating levels and pulse wave velocity. Postmenopausal women showed higher  PCSK 9 levels (309.9±84.1 ng/mL) compared with the other groups ( P <0.001). Older men had significant higher levels than younger men (283.2±75.6 versus 260.9±80.4 ng/mL;  P =0.008). In the whole sample, pulse wave velocity was predicted mainly by age (B=0.116, 95%  CI  0.96–0.127,  P <0.001),  PCSK 9 (B=0.014, 95%  CI  0.011–0.016,  P <0.001), and serum uric acid (B=0.313, 95%  CI  0.024–0.391,  P =0.026). Physical activity, low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol, and estimated glomerular filtration rate were not associated with pulse wave velocity ( P >0.05).By considering the subgroups described, age and  PCSK 9 levels were mainly associated with pulse wave velocity, which also correlated with serum uric acid in postmenopausal women.    Conclusions  In the Brisighella Heart Study cohort, circulating  PCSK 9 is significantly related to arterial stiffness, independent of sex and menopausal status in women.

journal of the american heart association

Circulating Levels of Proprotein Convertase Subtilisin/Kexin Type 9 and Arterial Stiffness in a Large Population Sample: Data From the Brisighella Heart Study